Ruin is out to kill Superman and those closest to him. He has unleased Replikon and his son to soften up the Man of Steel, but now he unleashes his deadliest attack yet - twin Parasites, who can sap the life from even a Kryptonian.
Along the way, Lois Lane, still recovering from a gunshot wound, Lana Lang and Jimmy Olsen are all threatened. And each time, Superman insists, no one will die on his watch. But Clark Kent's personal life and Superman's professional career are challenged by forces beyond his control, and not even counsel from Batman and Wonder Woman can help.